At 64, Rosie O'Donnell said she's reached a spot wherever she feels healthier and much comfortable successful her body.
"I ne'er felt better. And it's sad to maine that it took maine till I was 64 to get here, but portion of it is Mounjaro," O'Donnell said connected Tuesday's section of the "Good Hang pinch Amy Poehler" podcast.
The character and talk show big said her expert first introduced her to the supplier 3 years agone to thief negociate her diabetes.
"Never mentioned weight loss. Never said thing because it was my numbers they were trying to get down," O'Donnell said.
Not agelong aft starting the medication, O'Donnell said she noticed its effects during a celebratory meal for her son's engagement.
"I return the shot, and I spell retired to Nobu, and I can't eat anything," she said, adding that she initially thought her deficiency of appetite was owed to emotion affectional and wishing her precocious mother could person shared successful the occasion.
The weight loss that followed was truthful unexpected that O'Donnell said she feared thing was wrong.
"Cut to 2 weeks later, I get connected the scale. I telephone my expert crying, I must person cancer. I've mislaid 12 pounds, and I haven't done anything," she said.
"I had ne'er mislaid weight for nary reason," O'Donnell said, adding that losing weight had ever been difficult for her, moreover erstwhile she was actively trying to do so.
The FDA approved Mounjaro, which contains tirzepatide, for type 2 glucosuria successful 2022. A twelvemonth later, it approved the aforesaid drug for chronic weight management nether the marque sanction Zepbound.
Like semaglutide, the progressive constituent successful Ozempic and Wegovy, tirzepatide activates receptors for GLP-1, a gut hormone that helps modulate humor sweetener and appetite. Unlike semaglutide, tirzepatide besides activates receptors for different hormone, GIP.
Tirzepatide and semaglutide tin origin akin side effects, including gastrointestinal symptoms specified arsenic nausea and diarrhea.
O'Donnell is 1 of respective celebrities who person opened up astir their experiences taking GLP-1 medications.
In May 2025, "Modern Family" prima Eric Stonestreet told Business Insider that taking Mounjaro for his glucosuria yet motivated him to adopt a healthier lifestyle. He said he started moving for 150 minutes a week.
"All of a sudden, I felt for illustration I needed to beryllium accountable to it, because it's showing up each time to do thing for me," Stonestreet said.
In August 2025, Serena Williams said she turned to a GLP-1 aft struggling to suffer weight pursuing childbirth, contempt exercising and eating healthily.
"I mislaid complete 31 pounds utilizing my GLP-1 and I was really excited astir that weight loss," Williams said.
In January, Oprah Winfrey said she regrets not utilizing GLP-1s sooner to negociate her weight.
"I deliberation astir the wasted years," Winfrey said.
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Amanda is simply a elder manner newsman astatine Business Insider's Singapore bureau.Her reporting explores really group navigate awesome life transitions, including profession changes, relocation, and retirement, pinch a peculiar attraction connected the experiences of those surviving successful Asia. She besides writes astir travel, culture, wellness, and relationships.In 2025, she won the Singapore Press Club's Rising Stars Young Digital Journalist Award.She antecedently worked arsenic a writer and video shaper astatine a contented trading agency successful Singapore. She graduated from the University astatine Buffalo pinch a BA (Hons) successful Sociology.
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